Dr. Natalie Saini, National Scleroderma Foundation 2023 Established Investigator Awardee, is a co-author of groundbreaking research exploring the connection between systemic sclerosis and cancer risk.
The study reveals how inflammation and immune responses in systemic sclerosis may lead to DNA damage, driving mutations often seen in pre-cancerous tissues. Findings include increased mutation rates and unique signatures linked to cancer-like processes, providing vital insights into disease progression and complications.
Read more about this pivotal work here: Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis | Nature Communications